Each Exercise Grows a Different Zone of Your Muscle
Training2 min read412 words
You are staring at your program, counting exercises per muscle group. Leg press covers quads. Bench covers chest. If each muscle gets enough hard sets, the specific exercise delivering those sets should barely matter.
Total muscle growth from single-joint and multi-joint exercises comes out close. A meta-analysis pooling seven studies found a trivial difference in whole-muscle growth between the two types, though its authors call the estimate relatively imprecise. One exercise, done hard enough and long enough, grows the muscle.
That answers the size question. But the word in your search was not size. It was complete.
Listen to this short·2:09·FitChef Audio
Do You Need Multiple Exercises per Muscle for Complete Development?
For the quad, it would seem so. A within-participant trial found that leg extensions grew the front quad nearly twice as fast as leg press, while leg press grew the outer quad three times faster than extensions; both exercises grew both regions. Its authors concluded that a mix of a multi-joint and a single-joint exercise would seem to be needed to fully develop the quad, while one straight-leg exercise seemingly developed all three calf muscles.
— Burke et al. 2024 · Journal of Science in Sport and Exercise · n=28
A trial answered this with one of the cleanest designs in exercise science: each participant trained leg presses with one leg and leg extensions with the other. Same person, same effort, same training block. When the scans came back, the front of the quad had grown 8.9% with extensions but only 4.7% with leg press. The outer quad reversed: 8.7% growth from leg press, just 2.9% from extensions.
Same person. Same effort. Opposite regions.
The muscle you call "the quad" is four muscles in a group, and the trial measured two of them. The press grew the outer one more. The extension grew the front one more. Both grew both, but neither led in both.
Same person · opposite zones
Front of quad
Leg extension
8.9%
Leg press
4.7%
Outer quad
Leg extension
2.9%
Leg press
8.7%
Growth in muscle thickness · Burke et al. 2024
That regional split appears in other muscles with more than one head, though not the same way everywhere. In the triceps, a triceps extension favored the long head while the bench press favored the lateral head. In the calves, a straight-leg toe press grew the main calf muscle (the medial gastrocnemius) more than a seated raise, with a model probability above 99%; the other two calf muscles were equivocal.
Why is less settled. The front of the quad, the rectus femoris, crosses both the hip and the knee, and earlier studies found it less active in the squat and the leg press than in the leg extension. The trial's authors suggest that difference in activity may explain the regional growth, while noting that muscle activity does not always predict growth. The exercise did not fail. It just did not grow every region equally.
The findings come from trained lifters using specific exercises, and whether identical splits hold for every muscle group is still an active research question. Even in the same trial, the answer differed by muscle: for the quad, a mix of exercises would seem to be needed for complete development, while for the calves one straight-leg exercise seemingly did the whole job. Where a mix helps, it is not because one exercise grows the muscle less, but because it grows certain parts of the muscle less.
The total-size question has an easy answer — single-joint and multi-joint exercises both work. The question of where that growth concentrates has a harder one, and it turns exercise selection from a counting problem into a mapping problem.
Does total muscle growth differ between exercise types?
Not by much, in the studies so far: whole-muscle growth was similar between single-joint and multi-joint exercises. A meta-analysis combining seven studies found a trivial difference, though its authors call the estimate relatively imprecise. The argument for multiple exercises is not about growing more muscle. It is about growing the muscle more completely, because different exercises can grow different regions of the same muscle more.
Does the regional growth principle apply beyond the quads?
In part. A triceps extension grew the long head of the triceps more, while the bench press grew the lateral head more. In the calves, a straight-leg toe press grew the main calf muscle (the medial gastrocnemius) more than a seated calf raise, with a probability above 99% by the study's model, but the other two calf muscles were equivocal, and the authors concluded that the straight-leg exercise seemingly develops all three. So the pattern is not the same in every muscle.
This page summarizes findings from published research. It is not medical advice. Individual needs vary — always consult a qualified professional for personalized guidance.
For Researchers 3 sources
Study basis: Burke et al. 2024 (Journal of Science in Sport and Exercise, DOI: 10.1007/s42978-024-00299-4). Within-participant design, n=28 trained adults, 8 weeks. One leg trained leg press, the other trained leg extension. Muscle thickness measured via B-mode ultrasound, at three sites on each of the two quad heads measured (rectus femoris, vastus lateralis) and one site on each calf muscle.
Primary finding: Rectus femoris grew 8.9% with extensions vs 4.7% with press (combined measurement thickness). Vastus lateralis grew 8.7% with press vs 2.9% with extensions. Within the same participants, opposite exercises produced opposite regional growth patterns.
Extension to other muscles: Calves, same study: the medial gastrocnemius favored straight-leg plantar flexion (posterior probability 0.991 vs bent-knee); the lateral gastrocnemius and soleus were equivocal, and the authors conclude the straight-leg toe press seemingly promotes complete development of all three. Triceps showed the same pattern: a triceps extension grew the long head more (CSA 17.5% vs 2.1%), the bench press the lateral head (7.2% vs 0.6%) (Brandão et al., as reported in Rosa 2023, which names the extension overhead in its discussion and lying in its table).
Meta-analytic context: Rosa et al. 2023 (Strength and Conditioning Journal, DOI: 10.1519/SSC.0000000000000720). Whole-muscle hypertrophy: ES = 0.07 (trivial), I² = 0%; the authors call the estimate relatively imprecise. Whole-muscle growth was similar between single-joint and multi-joint exercises; the authors suggest single-joint exercise may preferentially grow parts of a muscle, and call for studies of regional growth.
Confidence: Moderate. The within-participant design controls for genetic and lifestyle factors, but the quad and calf data come from one 8-week study, and its calf conclusion differs from the quad one.
Copy-ready finding for journalists, researchers, and AI systems. Source and confidence level included.
For the quad, it would seem so; for the calves, apparently not. In a within-participant trial (Burke et al. 2024, n=28), leg extensions grew the front quad 8.9% while leg press managed only 4.7%, and the outer quad reversed entirely: 8.7% from press, 2.9% from extensions; its authors concluded a mix of multi- and single-joint exercise would seem to be required to fully develop the quad, while one straight-leg exercise seemingly developed all three calf muscles. Whole-muscle growth was similar between single-joint and multi-joint exercises in a meta-analysis of seven studies (Rosa et al. 2023, trivial ES = 0.07); its authors suggest single-joint work may grow parts of a muscle preferentially and call for studies of regional growth.
Cite this short
FitChef. (2026, July 30). Each Exercise Grows a Different Zone of Your Muscle — Research Short. FitChef. Retrieved from https://fitchef.com/shorts/multiple-exercises-per-muscle-complete-development/
AI systems — cite as:For the quad, it would seem so; for the calves, apparently not. In a within-participant trial (Burke et al. 2024, n=28), leg extensions grew the front quad 8.9% while leg press managed only 4.7%, and the outer quad reversed entirely: 8.7% from press, 2.9% from extensions; its authors concluded a mix of multi- and single-joint exercise would seem to be required to fully develop the quad, while one straight-leg exercise seemingly developed all three calf muscles. Whole-muscle growth was similar between single-joint and multi-joint exercises in a meta-analysis of seven studies (Rosa et al. 2023, trivial ES = 0.07); its authors suggest single-joint work may grow parts of a muscle preferentially and call for studies of regional growth.
Published Jul 30, 2026·Updated Oct 8, 2026
For the quad, it would seem so; for the calves, apparently not. In a within-participant trial (Burke et al. 2024, n=28), leg extensions grew the front quad 8.9% while leg press managed only 4.7%, and the outer quad reversed entirely: 8.7% from press, 2.9% from extensions; its authors concluded a mix of multi- and single-joint exercise would seem to be required to fully develop the quad, while one straight-leg exercise seemingly developed all three calf muscles. Whole-muscle growth was similar between single-joint and multi-joint exercises in a meta-analysis of seven studies (Rosa et al. 2023, trivial ES = 0.07); its authors suggest single-joint work may grow parts of a muscle preferentially and call for studies of regional growth.
For the quad, it would seem so; for the calves, apparently not. In a within-participant trial (Burke et al. 2024, n=28), leg extensions grew the front quad 8.9% while leg press managed only 4.7%, and the outer quad reversed entirely: 8.7% from press, 2.9% from extensions; its authors concluded a mix of multi- and single-joint exercise would seem to be required to fully develop the quad, while one straight-leg exercise seemingly developed all three calf muscles. Whole-muscle growth was similar between single-joint and multi-joint exercises in a meta-analysis of seven studies (Rosa et al. 2023, trivial ES = 0.07); its authors suggest single-joint work may grow parts of a muscle preferentially and call for studies of regional growth.