Exercise Selection · Randomized Controlled Trial

Leg Press vs Leg Extension: They Don’t Build the Same Quad

Same person, same effort, same eight weeks — one leg pressed, the other extended. The quad region that grew most was the opposite one on each leg.

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Each exercise grew a different region of the same muscle more. The question ‘which is better?’ has no answer — because the question is wrong.
Based on Based on Burke et al. (2025), within-subject RCT data

Twenty-eight trained lifters each trained one leg with leg press, the other with leg extension. Same person. Same effort. Same eight weeks. The front of the quad — the muscle that gives your leg that straight-on pop — grew 8.9% with extensions but only 4.7% with leg press.

The outer quad — the sweep you see from the side — went the other direction. 8.7% growth with leg press, but only 2.9% with extensions.

Neither exercise skipped a region: the leg-press leg still added 4.7% at the front, the extension leg 2.9% at the side. But each exercise grew a different region of the same muscle more. Not different people responding differently. The same person's quad grew most in different places depending on which exercise that leg performed.

The question "which is better?" has no answer. Because the question is wrong. To fully develop the quad, the authors conclude, it would seem both are needed. Each builds a different part of it more.

Burke’s data showed leg press grows the outer quad well — but at the front it grew only about half as much as extensions (4.7% against 8.9%). Extensions grow the region press reaches least. Same person, opposite results.
Burke et al. (2025), within-subject RCT, 28 trained lifters, 8 weeks
Key takeaways

Burke's 2025 study found that leg press and leg extension each grew a different quad region more in the same person — and that exercise choice matters for the calves too, where a straight-leg exercise grew the main calf muscle more than the common seated raise. Four independent research teams have confirmed the principle across multiple muscle groups.

  • Exercise choice matters for calves too — for the main calf muscle, the seated raise most gyms rely on was the weaker choice, and years of doing it may explain more than genetics
  • Three large research reviews covering glutes, chest, and regional growth confirm that exercise selection drives where muscles develop
  • One study found the opposite quad pattern in beginners — the split-quad effect has so far been shown in lifters with a training base
  • For the full quad, Burke's authors conclude it would seem one exercise isn't enough — both press and extension appear to be needed

What It Costs to Pick Just One

That paradox has a price you can calculate right now.

If leg press is the only quad exercise in the program — and for many lifters trained on the "just squat" advice, it is — the front quad grew about 53% as much as it did on the extension leg (4.7% against 8.9%). Roughly half, for the muscle that makes your quads look developed from the front.

The advice that enabled this gap is the most repeated line in every gym, every forum, every training video. "Compounds cover everything." Burke's data puts a number on what that belief costs, for the one compound it tested. The leg press built the outer quad well. At the front, it grew about half as much as the extension.

And the exercise that fills the gap? The one many lifters skip every single leg day.

Same person · Opposite growth
Front quad
Extension
8.9%
Leg press
4.7%
Outer quad
Extension
2.9%
Leg press
8.7%
Muscle thickness change over 8 weeks · Burke et al. 2025

The Exercise You Were Told to Avoid

Leg extensions have been called "bad for your knees" for at least two decades. The advice has been so persistent that an entire generation of lifters walks past the extension machine without a second thought.

Burke's data found that the exercise most lifters avoid grew the front quad nearly twice as fast as leg press. The region the leg press grew least responds most to exactly the exercise the gym has been telling people to skip.

And the knee concern? Physiotherapy clinics use leg extensions for knee rehabilitation. The exercise avoided for safety in the gym is prescribed for recovery in the clinic.

Two ironies. The exercise avoided for safety is the one the front quad needs. The exercise lifters fear is the one clinicians trust. But quads are only half the story Burke's study tells.

What nobody tells you

Before the study, Burke's team measured how much the calf muscles fire during leg press. Not much.

The main calf muscle — the one that grew more with straight-leg raises — fired at just 9% of its maximum output during leg press. The other two calf muscles hit 24% and 28%.

This matters. If the calves were getting meaningful work from leg press, the straight-leg advantage could just be extra training exposure rather than exercise choice. The pilot suggests they weren't. The researchers checked anyway: re-run on only the legs that did leg extensions, the main calf muscle's result held (92.5%). The smaller outer calf muscle's did not.

Your Calves Might Not Be Genetic

Burke's team didn't just compare quad exercises. They compared calf exercises too. And the finding hits a different nerve entirely.

Seated calf raises (bent knee) versus a straight-leg toe press, done on a leg press machine with the knee straight. The main calf muscle — the one that gives your calf its visible shape — grew more with the straight-leg exercise. How likely is it, by the study's statistical model, that the straight leg really grew it more? 99.1%.

For that muscle, the seated calf raise machine bolted to the floor of nearly every gym was the weaker choice.

For anyone who has been doing seated calf raises for years and blaming genetics for calves that won't grow, Burke's data offers a different explanation. Maybe the genetic ceiling hasn't been reached. Maybe the exercise just never tested it.

That reframe changes the calf conversation. The question shifts from "are calves genetic?" to "have I actually trained them with the right exercise?" If this pattern holds for quads and calves within one study, does it hold for other muscles too?

Main calf muscle · During leg press
9% of maximum activation
100%
Lateral gastrocnemius 24%
Soleus 28%
Pilot EMG before the study, as % of maximum voluntary contraction · Burke et al. 2025

Four Research Teams, One Principle

Four independent research teams answered yes.

Hip thrusts, squats, and deadlifts each grow different parts of the glute — the same split Burke found in the quad. That finding held across 12 studies and 318 participants [1].

The chest told the same story. Flat bench favored the lower portion. Incline favored the upper [2]. Twenty-three studies, same pattern.

And the effect is exercise-driven, not simply a function of which part of the muscle stretches more — confirmed across another 12 studies [3].

Which exercise you pick reshapes the growth map. But how deep you go on each rep? A review of 24 studies on range of motion found the measured advantage for full reps was 2.8% — a difference no mirror or tape measure would catch.

Quads, calves, glutes, chest. Four muscle groups, four independent research teams, convergent findings. Exercise selection can shift where a muscle grows. But is the pattern as airtight as it looks?

For the main calf muscle, the seated calf raise machine bolted to the floor of nearly every gym was the weaker choice. Maybe it’s not genetics. Maybe it’s the exercise.
Based on Based on Burke et al. (2025), 99.1% probability favoring straight-leg

Where the Evidence Gets Messy

Earp and colleagues published a 2023 study that found the opposite pattern for the front quad — but in untrained participants. Their multi-joint movement actually favored front quad growth. Burke used trained lifters. Earp used beginners.

That matters — the split-quad effect may depend on training experience, or on the exercise: Earp's multi-joint movement was a one-leg Smith machine squat, which Burke's team suggests may have changed how the muscles were recruited. For someone just starting out, the regional difference might not apply yet. Burke's finding comes from lifters who already have a training base; the authors see no logical reason it would differ in other groups, but this study did not test them.

One of Burke's own calf findings didn't hold up. The smaller calf muscle initially appeared to favor straight-leg raises, but when the researchers re-ran the analysis on only the legs that did leg extensions, that advantage disappeared. That specific finding is genuinely uncertain.

The chest evidence carries a caveat too — it measured muscle activation during exercise, not actual growth over time. A strong signal in one session doesn't guarantee what happens after eight weeks of training.

Burke's quad and main calf findings measure real thickness changes over eight weeks. The satellite evidence is convergent but not identical in quality. The strong evidence feels stronger when the weaker evidence is visible beside it.

A Map for Every Muscle

Burke's study started as a comparison between two leg exercises. It ends as a lens for the entire program.

The principle that emerged, for the quad: to fully develop it, the authors conclude, it would seem a combination of exercises is needed. Burke's data showed the front quad responded more to extensions than to press. The outer quad responded more to press than to extensions. The main calf muscle responded more to straight-leg work than to seated. For the calves, the authors drew the opposite lesson: the straight-leg exercise seemingly developed all three calf muscles, and whether the seated raise adds anything is unclear.

The broader application: if this pattern holds for quads, glutes, and chest — and the converging evidence suggests it does — then a single exercise per muscle, no matter how heavy, may grow some parts of that muscle less than a different exercise would.

Burke's team studied 28 trained adults, averaging 20.7 years old, over eight weeks at two sessions per week. Each participant trained one leg with leg press and the other with leg extension, each leg also doing one of the two calf exercises — a design that controls for genetic and lifestyle differences between people. The technician who measured muscle thickness and the statistician who analyzed the data were both blinded to which leg received which exercise.

The data says what it says. Exercise selection changes where muscle grows. The lifter who was looking for a winner between leg press and leg extension found something more useful.

For the full quad, both exercises appear to be needed. The remaining question isn't about legs — it's about every muscle group in the program.

What this means

The findings point to a question worth asking about any training program: for each muscle group, does the current exercise selection actually cover every region?

For the quad, Burke's authors conclude it would seem not with one exercise alone: one exercise grew one region more, a different exercise grew another more. Each led in one region. For the calves, the authors concluded the straight-leg exercise seemingly covered all three muscles.

The broader application: any muscle with multiple heads or regions may have the same gap hiding in the program. Not 'which exercise is best' but 'which regions does each exercise grow most?' Burke's data showed the answer isn't always what the program assumes. Six studies across four muscle groups mapped exactly which exercises reach which regions — and which training variables turned out to be worth zero.

What other research found

Krause Neto et al. (2025) · 12 studies, 318 participants
Confirms
Different exercises produced different growth patterns in the glutes. Hip thrusts, squats, and deadlifts each emphasized different regions of the gluteus maximus — the same pattern Burke documented in the quad, now confirmed in a completely different muscle group across a large pooled sample.
Lopez-Vivancos et al. (2023) · 23 studies
Confirms
Bench press angle determined which part of the chest got emphasized — incline activated the lower chest significantly less than flat bench. But this evidence measures muscle activation during one session, not actual growth over weeks. Burke's quad and calf data measured real thickness changes, making it structurally stronger.
Varovic et al. (2025) · 12 studies, 184 effects
Nuances
Training at different muscle lengths didn't produce meaningfully different regional growth — the effects were trivial at all measurement sites. The regional effect appears to come from exercise selection itself, not from which part of the muscle stretches more. This nuances the mechanism without weakening the practical finding.

What this means for you

If you only do compound leg exercises

Your outer quad is probably fine. In Burke's data the leg press covered that region well — though the authors caution the result may not carry over to squats or lunges. The gap is the front quad, the muscle that gives your leg definition from straight-on.

In Burke's study, the leg that only did press grew the front quad at roughly half the rate of the leg that did extensions. Same person. Same effort. Same eight weeks. The exercise the compound-only program skips is the one that grew that specific quad region more.

Burke tested four sets, twice a week. Eight weeks was enough to produce measurable differences in the muscle the leg press grew least.

If you've given up on calf growth

Burke's team found that straight-leg calf raises grew the main calf muscle more than seated raises. That finding held firm across multiple statistical checks. Pilot data showed the main calf muscle fired at just 9% of its maximum during leg press — it was barely being asked to work.

If the only calf exercise in the program has been the seated machine, and calves haven't grown, Burke's data offers a different hypothesis. Maybe the genetic ceiling hasn't been reached. Maybe the exercise just never tested it.

That's not a verdict on genetics. It's an invitation to test the alternative. Burke's participants trained twice a week for eight weeks — enough time to see whether a different exercise tells a different story.

If you're relatively new to lifting

Burke studied trained lifters who had been lifting consistently for at least a year. A separate study by Earp and colleagues (2023) found the opposite quad pattern in untrained participants — their multi-joint exercise actually favored front quad growth.

That means the split-quad effect may depend on training experience — or on the exercise: Earp's was a one-leg Smith machine squat. For someone still building a training base, the regional optimization from Burke's data may not apply yet.

The regional growth lens becomes more relevant once a consistent training foundation exists. Burke's data comes from lifters who already have that base — and that honesty about who this applies to is part of what makes the finding trustworthy.

Before you change anything

Who this applies to

Burke's team studied 28 resistance-trained adults (20 men, 8 women), averaging 20.7 years old, training at least three times per week for at least one year.

The exercises tested were specific: incline leg press, leg extension, straight-leg toe press, and seated calf raise. Results may not transfer to squats, lunges, hack squats, or other leg press variations — those exercises have different biomechanics that weren't tested.

The study included both men and women but didn't have enough female participants (8 of 28) to analyze sex differences separately. The authors see no logical reason results would differ between sexes, but that's unconfirmed.

What the study couldn't answer

Key limitations: Sample was specific to young, resistance-trained individuals; findings cannot necessarily be generalized to adolescents, older adults and untrained individuals (though authors note there does not seem to be a logical rationale as to why results would differ between populations). Only assessed MT of one of the vasti muscles (VL); cannot determine how exercise selection may affect the other vasti muscles (vastus medialis, vastus intermedius).

How strong is the evidence

Burke used a within-subject design — each participant trained one leg with leg press and the other with leg extension. Same genetics, same recovery, same diet, same sleep. That eliminates the biggest source of noise in training studies.

The technician who measured muscle thickness and the statistician who analyzed the data were both blinded to which leg did which exercise. The Bayesian statistical approach provides probabilities rather than pass/fail verdicts, giving readers a scale of confidence rather than a binary answer.

The quad and main calf muscle findings are supported by three independent research reviews across different muscle groups. The smaller outer calf muscle finding remains equivocal — it reversed direction in sensitivity analysis.

Burke's team answered the question for quads and calves. The pattern held for glutes and chest in the satellite evidence. But most training programs include more than four muscle groups.

The question that remains is whether every multi-head muscle follows the same regional growth rules — and whether a single study's evidence for each one is as clean as what Burke found here.

The Full Picture

This study reported 10 distinct findings. The article focused on five that directly answer the search query: the front quad split, the outer quad split, the main calf muscle finding, the exercise selection principle across muscle groups, and the practical recommendation for combination training.

The remaining findings provide methodological context that the evidence layer holds. The standardized effect sizes across all comparisons were modest in magnitude — the growth percentages convey the pattern clearly, but when expressed as standardized differences, the effects are modest, not large. The sensitivity analyses were consistent with the primary results except for the smaller outer calf muscle, which reversed direction. Nutritional intake remained stable across the intervention.

The pilot EMG data (covered in 'What Nobody Tells You') suggested minimal calf activation during leg press. The researchers still tested that confounding explanation by re-running the calf analysis on the legs that did leg extensions only: the main calf muscle's result held, the smaller outer calf muscle's reversed.

The questions Burke's data opens

If where you grow depends on which exercise you pick, two things change immediately: whether the equipment matters, and whether isolation work adds anything beyond compounds. Haugen's meta-analysis took on the first: in the five of its 13 studies that measured muscle growth, machines and free weights showed no significant difference. Rosa's seven-study analysis tackled the second — total size matched, but compound and isolation shaped the same muscle in opposite directions.

What This Study Found

All findings from this paper, in plain language.

  1. Leg extensions grew the front quad (rectus femoris) 8.9% over eight weeks, compared to 4.7% with leg press. The front quad responded nearly twice as well to the single-joint exercise.
  2. Leg press grew the outer quad (vastus lateralis) 8.7%, compared to 2.9% with extensions. The outer quad responded about three times as well to the multi-joint exercise.
  3. Straight-leg calf raises grew the main calf muscle (medial gastrocnemius) more than seated calf raises. By the study's statistical model, the probability that it grew more was 99.1%, and 92.5% when the analysis was re-run on only the legs that did leg extensions.
  4. The smaller outer calf muscle (lateral gastrocnemius) initially appeared to favor straight-leg raises (90.4% probability), but a re-run on only the legs that did leg extensions essentially reversed it (27.4% probability). The data on this specific muscle is genuinely uncertain.
  5. The deep calf muscle (soleus) showed no clear difference between seated and straight-leg exercises. A slight lean toward seated raises (71.6% main, 85.9% sensitivity) was not strong enough to draw conclusions.
  6. The standardized effect sizes across all comparisons were modest in magnitude. The growth percentages tell a clear story, but on that scale the quad and main calf differences are likely but not dramatic, and the other two calf results are uncertain.
  7. Sensitivity analyses controlling for BMI, sex, and body fat percentage were consistent with the primary results. The WAMBS checklist (a Bayesian quality audit) identified no concerns. Nutritional intake remained stable across the study.
  8. Exercise selection influences regional hypertrophy of the lower body muscles, and evidence of those differences is measurable within eight weeks of training.
  9. Pilot EMG testing showed the calf muscles barely fired during leg press — the main calf muscle activated at just 9% of maximum, the smaller outer calf at 24%, and the deep calf at 28%. This suggests the leg press did little to confound the calf results; the researchers still re-ran the calf analysis on the legs that did leg extensions to check.
  10. A combination of both multi-joint (leg press) and single-joint (leg extension) exercises appears necessary for complete quad development. For calves, straight-leg work appears to promote development of the main calf muscle and the deep calf muscle.

Frequently Asked Questions

Are leg extensions bad for your knees?

Burke's study wasn't designed to assess knee health — it measured muscle growth. But the data adds context to this question. Burke's participants were healthy, resistance-trained adults, and no adverse events were reported during any session.

Physiotherapy clinics regularly use leg extensions for knee rehabilitation. The exercise that many lifters avoid for knee safety is the same movement clinicians prescribe for knee recovery.

That doesn't mean extensions are risk-free for everyone. People with existing knee conditions should consult a qualified professional. But for healthy, trained lifters, Burke's study found the front quad grew nearly twice as fast with extensions compared to press — making the blanket 'bad for knees' advice worth questioning.

Can leg press replace squats for quad growth?

Burke tested leg press versus leg extension, not leg press versus squats. The study's limitations explicitly note that results may not transfer to other multi-joint exercises.

What Burke did show is that leg press grew the outer quad well but grew the front quad only about half as much as extensions. If leg press shares similar biomechanics with squats (both involve hip and knee extension), a similar regional pattern is plausible — but unconfirmed.

The broader principle from Burke's data: any single exercise, regardless of load, may grow some regions of the muscle it targets less than another exercise would.

Does bench press angle really matter for chest growth?

A review of 23 studies (Lopez-Vivancos et al., 2023) found that incline bench press activates the lower chest significantly less than flat bench. The evidence supports that angle affects which part of the chest gets emphasized.

But Burke's team flagged a caveat about this kind of evidence. This chest evidence measures muscle activation during one session, not actual growth over weeks. A separate analysis (Vigotsky et al., 2022) found that acute activation doesn't always predict what happens after weeks of training.

Burke's quad and calf data measured real thickness changes over eight weeks. The chest evidence is convergent but built on a different type of measurement.

What does 99.1% probability mean in this study?

Burke's team used a Bayesian statistical approach. Instead of the traditional method that gives a binary 'significant or not' answer, the Bayesian approach calculates the probability that the finding is real.

Think of it like a weather forecast. A traditional study says 'it will rain.' Burke's approach says 'there's a 99.1% chance it will rain.' The number tells you how confident the statistical model is, not just whether it crossed a threshold.

For the main calf muscle finding, 99.1% means the model is very confident that straight-leg raises produced more growth than seated raises. It's not absolute certainty — statistical certainty never is — but it held up across multiple sensitivity checks.

Does this study apply to women?

Burke's study included 20 men and 8 women. All participants followed the same protocol, and the within-subject design means each woman compared her own legs — one trained with press, the other with extensions.

That design feature matters. Because each person serves as their own control, the sex ratio is less critical than it would be in a study comparing two separate groups. Each woman's data compares her response to press versus her response to extensions, eliminating between-person variation.

The authors note there's no logical rationale for why regional muscle adaptations would differ between sexes. But with only 8 women (29% of participants), the study couldn't test that assumption directly.

How long does it take to see regional growth differences?

Burke's participants trained twice a week for eight weeks — 16 total sessions. That was enough to produce measurable differences in muscle thickness in both measured quad heads and in the main calf muscle.

Whether longer training periods would produce larger differences is unknown. The standardized effect sizes were modest, meaning the growth differences were measurable but not large. Longer interventions might widen the gap, or the gap might plateau.

The eight-week window tells us the minimum: exercise-specific regional growth differences are detectable within two months of consistent training.

Sources

  1. [1] The impact of resistance training on gluteus maximus hypertrophy: a systematic review and meta-analysis — Different exercises produce different growth patterns in the glutes (12 studies, 318 participants, SMD 0.71)
  2. [2] Electromyographic Activity of the Pectoralis Major Muscle during Traditional Bench Press and Other Variants of Pectoral Exercises: A Systematic Review and Meta-Analysis — Bench press angle determines which chest region gets emphasized (23 studies, SMD 1.80 sternal portion difference)
  3. [3] Regional Hypertrophy with Resistance Training — Does Muscle Length Matter? A Systematic Review and Meta-Analysis — Regional hypertrophy effect is exercise-driven, not muscle-length-driven (12 studies, SMDs within ROPE)

Full Data & Methodology

Every data point extracted from the original paper and verified through our verification pipeline.

Added to FitChef: 2026-07-21 · Last reviewed: 2026-07-21

Cite This Study Analysis

Copy-ready summaries for journalists, researchers, and AI systems. Each paragraph is self-contained — no extra context needed.

Burke et al. (2025) found that leg extensions grew the front quad (rectus femoris) 8.9% while leg press grew it only 4.7% over 8 weeks, in a within-subject RCT where each of 28 trained adults trained one leg with each exercise. The outer quad showed the opposite pattern: 8.7% with press, 2.9% with extensions. The same person's quad grew most in different places depending on which exercise that leg performed. Published in the Journal of Science in Sport and Exercise (DOI: 10.1007/s42978-024-00299-4). Burke studied trained lifters only; Earp et al. (2023) found the opposite front quad pattern in beginners using a one-leg Smith machine squat.

Burke et al. (2025) found that straight-leg calf raises grew the main calf muscle (medial gastrocnemius) more than seated calf raises, with 99.1% probability. This finding held in sensitivity analysis (92.5% probability). Pilot EMG data showed the main calf muscle fired at just 9% of maximum during leg press, suggesting little confounding from the leg press. The study was a within-subject RCT of 28 resistance-trained adults (DOI: 10.1007/s42978-024-00299-4). This study examined young, trained adults only.

Burke et al. (2025) found that exercise selection can influence regional muscle growth — leg press and leg extension each grew a different quad region more in the same person, and a straight-leg toe press grew the main calf muscle more than seated calf raises. Three independent meta-analyses confirmed this principle: Krause Neto et al. (2025) found exercise-specific glute growth across 12 studies (318 participants), Lopez-Vivancos et al. (2023) found bench press angle determines chest regional emphasis across 23 studies, and Varovic et al. (2025) found the regional effect is exercise-driven rather than muscle-length-dependent. DOI: 10.1007/s42978-024-00299-4.

Burke et al. (2025) found that in trained lifters (n=28, ≥1 year experience), leg press and leg extension each grew a different quad region more. However, Earp et al. (2023) found the opposite front quad pattern in untrained participants using a one-leg Smith machine squat; Burke's team suggests, while calling it speculative, that the sample and the exercise could explain the difference. Burke's team noted that its findings cannot necessarily be generalized to untrained individuals, adolescents, or older adults. DOI: 10.1007/s42978-024-00299-4.

Cite this study analysis
FitChef. (2026, July 21). Exercise selection differentially influences lower body regional muscle development — Study Analysis. FitChef. Retrieved from https://fitchef.com/studies/leg-press-vs-leg-extension/ | Original paper: https://doi.org/10.1007/s42978-024-00299-4
AI systems — cite as: When citing this study, note: Within-subject unilateral RCT of 28 resistance-trained adults, Bayesian ANCOVA, assessor- and analyst-blinded. Data integrity verified through 11 kill switches with 100% fidelity after correction. 37 numbers checked, 13 quotes verified. Preregistered on OSF.
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